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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SETD2 All Species: 6.06
Human Site: T1380 Identified Species: 22.22
UniProt: Q9BYW2 Number Species: 6
    Phosphosite Substitution
    Charge Score: 0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9BYW2 NP_054878.5 2564 287550 T1380 S S N S I K D T L A V N E K K
Chimpanzee Pan troglodytes XP_516423 2549 285788 D1373 L A V N E K K D F S K N L E K
Rhesus Macaque Macaca mulatta XP_001113652 2550 286209 T1366 S S N S I K D T L A V N E K K
Dog Lupus familis XP_864158 2562 287091 D1377 I S S N S I K D S L S M N E K
Cat Felis silvestris
Mouse Mus musculus
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_418510 2354 262767 S1240 Q E V A P Q D S S M V G R P C
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783359 3042 342758 G1439 G L D L E V N G A G D N Q A M
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q2LAE1 1759 193210 R645 L Q S S D S M R D K K Y N Q D
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.6 96.9 92 N.A. N.A. N.A. N.A. N.A. 61.7 N.A. N.A. N.A. N.A. N.A. N.A. 24.7
Protein Similarity: 100 98.9 98 94.6 N.A. N.A. N.A. N.A. N.A. 71.5 N.A. N.A. N.A. N.A. N.A. N.A. 41.6
P-Site Identity: 100 20 100 13.3 N.A. N.A. N.A. N.A. N.A. 13.3 N.A. N.A. N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: 100 46.6 100 33.3 N.A. N.A. N.A. N.A. N.A. 33.3 N.A. N.A. N.A. N.A. N.A. N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. 20.7 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 35.9 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 15 0 15 0 0 0 0 15 29 0 0 0 15 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 15 % C
% Asp: 0 0 15 0 15 0 43 29 15 0 15 0 0 0 15 % D
% Glu: 0 15 0 0 29 0 0 0 0 0 0 0 29 29 0 % E
% Phe: 0 0 0 0 0 0 0 0 15 0 0 0 0 0 0 % F
% Gly: 15 0 0 0 0 0 0 15 0 15 0 15 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 15 0 0 0 29 15 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 43 29 0 0 15 29 0 0 29 58 % K
% Leu: 29 15 0 15 0 0 0 0 29 15 0 0 15 0 0 % L
% Met: 0 0 0 0 0 0 15 0 0 15 0 15 0 0 15 % M
% Asn: 0 0 29 29 0 0 15 0 0 0 0 58 29 0 0 % N
% Pro: 0 0 0 0 15 0 0 0 0 0 0 0 0 15 0 % P
% Gln: 15 15 0 0 0 15 0 0 0 0 0 0 15 15 0 % Q
% Arg: 0 0 0 0 0 0 0 15 0 0 0 0 15 0 0 % R
% Ser: 29 43 29 43 15 15 0 15 29 15 15 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 29 0 0 0 0 0 0 0 % T
% Val: 0 0 29 0 0 15 0 0 0 0 43 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 15 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _